AgedBrainSYSBIO

The AgedBrainSYSBIO project on systems biology of synapse proteins & ageing was officially launched March 18th 2013 in Paris, France.

Gene Bridges is involved in AgedBrainSYSBIO as part of a multidisciplinary consortium assembling 14 academic and industrial internationally renowned research teams from Belgium, Estonia, France, Germany, Israel, United Kingdom and Switzerland. AgedBrainSYSBIO is a European collaborative research project funded by the European Commission under the Health Work Programme of the 7th Framework Programme.

Ageing is undisputedly a complex process because it affects the deterioration of most (if not all) aspects of life. Cognitive decline is emerging as one of the greatest public health challenges of the old age, with nearly 50% of adults over 85 afflicted by Alzheimer’s disease, the most common type of dementia.

Neurons
Cortical mouse neurons 7 div labeled with AUTS2 (red), Tau(green) and Dapi(blue) (10µm)
© Inserm, Malik Khelfaoui (U894)

As other chronic and neurodegenerative diseases, Alzheimer’s disease develops slowly and gradually. In 2013, it is estimated that there are worldwide more than 24 million people with Alzheimer’s disease, with 4.6 million new cases each year, which means a new case each 7 seconds. It is thus one of the greatest challenges in public health for modern societies, in terms of costs but also in terms of cause, cure and care.

To address all these issues, European Commission-funded research effort is crucial as there are still no curative drugs, with only symptomatic treatment able to delay the disease progression. Together, researchers will address the basis of brain ageing by studying the pathways involved in Late-Onset Alzheimer Diseases combining integrative systems biology and comparative genomics.

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